The acquisition of mutations in blood-forming stem cells is a hallmark of aging that has been neglected in the context of diseases other than cancer until very recently. Human studies show that people carrying specific acquired mutations in blood cells (a condition called clonal hematopoiesis) exhibit high mortality rates, mainly due to cardiovascular disease. In that context, we and other scientists have observed a potential connection between these mutations and the development of aggravated heart failure, a disease that develops when your heart doesn’t pump enough blood for the body’s needs. Through studies in humans and experiments in mice, this project will investigate in depth the effect of somatic mutations and clonal hematopoiesis on heart failure. The ultimate goal is to use this knowledge to improve the management of heart failure patients, who frequently require multiple hospitalizations.
Dr. Fuster is Assistant Professor, Head of the Hematovascular Pathophysiology Laboratory, and Coordinator of the Atherosclerosis Research Program at CNIC.
Dr. Pascual is the leader of the Experimental and Clinical Cardiology group at the IMIB (Instituto Murciano de Investigación Biosanitaria, part of FFIS).
Dr. Bayés-Genís is the Head of ICREC (Heart Failure and Cardiac Regeneration Laboratory) and Director of iCor (Heart Research Institute at IGTP), Cardiology Chief at Trias i Pujol Hospital and Associate Professor at the University Autónoma de Barcelona.
Dr. López-Bigas is a Research Professor at the IRBB, Associate Professor at the University Pompeu Fabra, and leader of the Biomedical Genomics lab at IRBB.
Dr Manel Esteller Badosa is the director of the Josep Carreras Leukaemia Research Institute and leader of the Cancer Epidenetics group.
Zuriaga MA, Yu Z, Matesanz N, Truong B, Ramos-Neble BL, Asensio-López MC, Uddin MM, Nakao T, Niroula A, Zorita V, Amorós-Pérez M, Moro R, Ebert BL, Honigberg MC, Pascual-Figal D, Natarajan P, Fuster JJ.
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